news1

2 Postdoc positions are currently opened and granted in Pierre Sonveaux’s lab at UClouvain, Brussels, Belgium

ISCaM Travel Awards

ISCAM training award

ISCaM Travel Awards

Notifications POSTPONED

ISCaM2021 – Nav Chandel talk

Nav Chandel - Mitochondria control cancer and adaptive immunity

ISCaM2021 – Costas Lyssiotis’ talk

Costas Lyssiotis - Metabolic Networks in the Tumor Microenvironment

Call for papers

Special Issue "Metabolic Networks in Cancer"

SAVE THE DATE! 9th ISCaM Annual Meeting

ISCaM Annual Meeting will return in-person in 2022

Session 4 – ISCaM2021 Webinar Series

Targeting Metabolism in Cancer

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

Oncogenesis 2021 Jan

Inflammation-induced cholestasis in cancer cachexia

J Cachexia Sarcopenia Muscle 2021 Feb

Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential

Br J Cancer 2021 Jan

Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer

Br J Cancer 2021 Feb

Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability

Eur J Dent. 2021 Feb

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia

Circulation 2021 Feb

General Assembly announced for the 20 October 2020

BOARD General Assembly announced for the 20 October 2020

Annual meeting report

The report of ISCAM2018 annual meeting has been published

Next EMBO workshop

Next EMBO workshop: Lactate: Unconventional roles of a nutrient along tumor landscape

Launching ISCaM exchange grant

Thursday, 25 April 2019

Conference announcement

Wednesday, 20 June 2018

Metabolic Profiling of healthy and cancerous tissues in 2D and 3D

14 December 2017

Conference announcement

Wednesday, 1 March 2017

Tumor metabolism, cancer cell transporters, and microenvironmental resistance

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells

15 May 2016

Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas

10 May 2016

Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism

22 March 2016

Monocarboxylate transporters in the brain and in cancer

16 March 2016

Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism

8 December 2015

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

4 December 2015

Lactate promotes glutaminolysis in oxidative cancer cells

4 December 2015

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

14 October 2015

Lactate does not activate NF-κB in oxidative tumor cells

Tuesday, 13 October 2015

The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

16 May 2015

Metabolism and its sequelae in cancer evolution and therapy

1 April 2015

Common responses of tumors and wounds to hypoxia

1 April 2015

NADH-linked metabolic plasticity of MCF-7 breast cancer cells surviving in a nutrient-deprived microenvironment

24 January 2015

Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

18 January 2015

Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD

20 October 2014

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

15 September 2014

A mitochondrial switch promotes tumor metastasis

7 August 2014

Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway

1 April 2014

Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

12 February 2014

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies

12 February 2014

V-ATPase as an effective therapeutic target for sarcomas

1 January 2014

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs

14 November 2013

Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells

2 October 2013

Disrupting proton dynamics and energy metabolism for cancer therapy

13 September 2013

Acidic extracellular microenvironment and cancer

3 September 2013

Oncogenes induce the cancer-associated fibroblast phenotype

1 September 2013

Proton pump inhibitor selectively suppresses proliferation and restores the chemosensitivity of gastric cancer cells by inhibiting STAT3 signaling pathway.

20 August 2013

NaV1.5 sodium channels allosterically regulate the NHE-1 exchanger and promote breast cancer cell invadopodial activity

2 August 2013

DNA methylation of the SLC16A3 promoter regulates expression of the human lactate transporter MCT4 in renal cancer with consequences for clinical outcome.

2 August 2013

Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes

2 August 2013

V-ATPase is a candidate therapeutic target for Ewing sarcoma

1 August 2013

Inhibition of vacuolar H+ ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells

14 July 2013

Expression of Monocarboxylate Transporter (MCT)-4 in Colorectal Cancer and its Role

14 July 2013

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux

9 July 2013

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

3 July 2013

Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma.

1 July 2013

Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho‑LRP6 expression in Wnt/β-catenin signaling

1 July 2013

Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors

4 June 2013

The Expression of Glut-1, CAIX, and MCT4 in Mucinous Carcinoma

2 June 2013

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

1 June 2013

Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis

1 February 2013

Histone acetylation regulates intracellular pH

24 January 2013

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

1 October 2012

Autophagy is a protective mechanism for human melanoma cells under acidic stress

31 August 2012

Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma

30 July 2012

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes

1 June 2012

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

1 March 2012